概述

  • 产品名称Anti-Lipin 2抗体
    参阅全部 Lipin 2 一抗
  • 描述
    兔多克隆抗体to Lipin 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide surrounding amino acid 871 of mouse Lipin 2

  • 阳性对照
    • Jurkat cell and Mouse tissue lysates.

性能

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应用

Our Abpromise guarantee covers the use of ab63928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 4 µg/ml. Detects a band of approximately 99 kDa (predicted molecular weight: 99 kDa).

靶标

  • 功能Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.
  • 组织特异性Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
  • 疾病相关Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS) [MIM:609628]. An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration).
  • 序列相似性Belongs to the lipin family.
  • 结构域Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
    Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.
  • 细胞定位Nucleus. Cytoplasm > cytosol. Endoplasmic reticulum membrane. Translocates to endoplasmic reticulum membrane with increasing levels of oleate.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KIAA0249 antibody
    • Lipin-2 antibody
    • Lipin2 antibody
    • LPIN 2 antibody
    • LPIN2 antibody
    • LPIN2_HUMAN antibody
    • OTTHUMP00000162242 antibody
    • Phosphatidate phosphatase LPIN2 antibody
    see all

Anti-Lipin 2 antibody 图像

  • All lanes : Anti-Lipin 2 antibody (ab63928) at 0.5 µg/ml

    Lane 1 : Jurkat cell lysate
    Lane 2 : Mouse tissue lysate


    Predicted band size : 99 kDa
    Observed band size : 99 kDa

Anti-Lipin 2 antibody (ab63928)参考文献

This product has been referenced in:
  • Zhang C  et al. Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling. Proc Natl Acad Sci U S A 109:1667-72 (2012). WB ; Mouse . Read more (PubMed: 22307628) »

See 1 Publication for this product

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