This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

概述

性能

应用

  • 应用说明This antibody gave a positive result in ELISA against the immunizing peptide.
    Antibody detection limit dilution 1:8,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.
    • 组织特异性Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
    • 疾病相关Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS) [MIM:609628]. An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration).
    • 序列相似性Belongs to the lipin family.
    • 结构域Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
      Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.
    • 细胞定位Nucleus. Cytoplasm > cytosol. Endoplasmic reticulum membrane. Translocates to endoplasmic reticulum membrane with increasing levels of oleate.
    • Information by UniProt
    • 数据库链接
    • 别名
      • KIAA0249 antibody
      • Lipin-2 antibody
      • Lipin2 antibody
      • LPIN 2 antibody
      • LPIN2 antibody
      • LPIN2_HUMAN antibody
      • OTTHUMP00000162242 antibody
      • Phosphatidate phosphatase LPIN2 antibody
      see all

    Anti-Lipin 2 antibody (ab28765)参考文献

    ab28765 has not yet been referenced specifically in any publications.

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