概述

  • 产品名称Anti-Lipin 2抗体
    参阅全部 Lipin 2 一抗
  • 描述
    兔多克隆抗体to Lipin 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide, corresponding to a region within C terminal amino acids 837-886 (ELIQERTKGN KSSYHRLSEL VEHVFPLLSK EQNSAFPCPE FSSFCYWRDP) of Human Lipin 2 (NP_055461).

  • 阳性对照
    • HeLa cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab117933 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 99 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.
  • 组织特异性Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
  • 疾病相关Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS) [MIM:609628]. An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration).
  • 序列相似性Belongs to the lipin family.
  • 结构域Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
    Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.
  • 细胞定位Nucleus. Cytoplasm > cytosol. Endoplasmic reticulum membrane. Translocates to endoplasmic reticulum membrane with increasing levels of oleate.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KIAA0249 antibody
    • Lipin-2 antibody
    • Lipin2 antibody
    • LPIN 2 antibody
    • LPIN2 antibody
    • LPIN2_HUMAN antibody
    • OTTHUMP00000162242 antibody
    • Phosphatidate phosphatase LPIN2 antibody
    see all

Anti-Lipin 2 antibody 图像

  • Anti-Lipin 2 antibody (ab117933) at 1 µg/ml + HeLa cell lysate at 10 µg

    Predicted band size : 99 kDa

Anti-Lipin 2 antibody (ab117933)参考文献

ab117933 has not yet been referenced specifically in any publications.

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