概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列(C)PFENQDIHSASA
    • 氨基酸879 to 890

技术指标

Our Abpromise guarantee covers the use of ab45702 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

    Neutralising

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • EC=3.1.3.4
    • KIAA0188
    • Lipin-1
    • Lpin1
    • LPIN1_HUMAN
    • PAP1
    • Phosphatidate phosphatase LPIN1
    see all
  • 功能Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.
  • 组织特异性Abundant in adipose tissue and skeletal muscle. Lower levels in some portions of the digestive tract.
  • 疾病相关Defects in LPIN1 are a cause of autosomal recessive acute recurrent myoglobinuria (ARARM) [MIM:268200]; also known as acute recurrent rhabdomyolysis. Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness and followed by excretion of myoglobin in the urine. Renal failure may occasionally occur. Onset is usually in early childhood under the age of 5 years.
  • 序列相似性Belongs to the lipin family.
  • 结构域Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which mediates interaction with PPARA.
    Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.
  • 翻译后修饰Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway (By similarity). Dephosphorylated in response to epinephrine and oleic acid.
    Sumoylated.
  • 细胞定位Nucleus. Cytoplasm > cytosol. Endoplasmic reticulum membrane.
  • Information by UniProt

Lipin 1 peptide (879-890) (ab45702)参考文献

ab45702 has not yet been referenced specifically in any publications.

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