概述

  • 产品名称Anti-LIPH抗体
    参阅全部 LIPH 一抗
  • 描述
    兔多克隆抗体to LIPH
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to internal sequence amino acids 259-308 (LRESCTITAY PCDSYQDYRN GKCVSCGTSQ KESCPLLGYY ADNWKDHLRG) of Human LIPH (NP_640341).

  • 阳性对照
    • THP1 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab118303 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 51 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
  • 组织特异性Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently expressed in hair follicles, including the stem cell-rich bulge region.
  • 疾病相关Defects in LIPH are the cause of hypotrichosis localized autosomal recessive type 2 (LAH2) [MIM:604379]; also known as alopecia universalis congenita Mari type. A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes.
    Defects in LIPH are the cause of woolly hair autosomal recessive type 2 (ARWH2) [MIM:604379]. A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrexis nodosa and tapered ends. Some individuals may present with hypotrichosis.
  • 序列相似性Belongs to the AB hydrolase superfamily. Lipase family.
  • 细胞定位Secreted. Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AH antibody
    • ARWH2 antibody
    • LAH2 antibody
    • Lipase H antibody
    • Lipase member H antibody
    • LIPH antibody
    • LIPH_HUMAN antibody
    • LPD lipase related protein antibody
    • LPD lipase-related protein antibody
    • LPDLR antibody
    • Membrane associated phosphatidic acid selective phospholipase A1 alpha antibody
    • Membrane bound phosphatidic acid selective phospholipase A1 antibody
    • Membrane-associated phosphatidic acid-selective phospholipase A1-alpha antibody
    • mPA PLA1 antibody
    • mPA-PLA1 alpha antibody
    • MPAPLA1 antibody
    • OTTHUMP00000210343 antibody
    • OTTHUMP00000210344 antibody
    • Phospholipase A1 member B antibody
    • PLA1B antibody
    see all

Anti-LIPH antibody 图像

  • Anti-LIPH antibody (ab118303) at 1 µg/ml + THP1 cell lysate at 10 µg

    Predicted band size : 51 kDa

Anti-LIPH antibody (ab118303)参考文献

ab118303 has not yet been referenced specifically in any publications.

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