概述

  • 产品名称Anti-LIN7B抗体
    参阅全部 LIN7B 一抗
  • 描述
    兔多克隆抗体to LIN7B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Zebrafish
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 57 and 204 of Human LIN7B (AAH27618).

  • 阳性对照
    • 293T and A431 whole cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab101339 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 23 kDa.

靶标

  • 功能Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.
  • 序列相似性Belongs to the lin-7 family.
    Contains 1 L27 domain.
    Contains 1 PDZ (DHR) domain.
  • 结构域The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
    The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
    The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
  • 细胞定位Cell membrane. Basolateral cell membrane. Cell junction. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > tight junction. Cell junction > synapse > synaptosome. Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hVeli2 antibody
    • hLin7B antibody
    • hVeli2 antibody
    • Lin 7 homolog B C elegans antibody
    • LIN 7B antibody
    • Lin 7b protein likely ortholog of mouse LIN 7B mammalian LIN 7 protein 2 antibody
    • Lin-7B antibody
    • LIN7B antibody
    • LIN7B_HUMAN antibody
    • MALS 2 antibody
    • MALS-2 antibody
    • MALS2 antibody
    • Mammalian lin seven protein 2 antibody
    • Mammalian lin-seven protein 2 antibody
    • Protein lin 7 homolog B antibody
    • Protein lin-7 homolog B antibody
    • VELI 2 antibody
    • Veli-2 antibody
    • VELI2 antibody
    • Vertebrate lin 7 homolog 2 antibody
    • Vertebrate lin-7 homolog 2 antibody
    see all

Anti-LIN7B antibody 图像

  • Anti-LIN7B antibody (ab101339) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size : 23 kDa

Anti-LIN7B antibody (ab101339)参考文献

ab101339 has not yet been referenced specifically in any publications.

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