概述

  • 产品名称Anti-LIN7抗体
    参阅全部 LIN7 一抗
  • 描述
    兔多克隆抗体to LIN7
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to amino acids 191-205 of LIN7.

  • 阳性对照
    • Tested with rat brain extract.

性能

应用

Our Abpromise guarantee covers the use of ab11472 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2.5 µg/ml. Predicted molecular weight: 20-25 kDa.

靶标

  • 功能Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
  • 序列相似性Belongs to the lin-7 family.
    Contains 1 L27 domain.
    Contains 1 PDZ (DHR) domain.
  • 结构域The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
    The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
    The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
  • 细胞定位Cell membrane. Basolateral cell membrane. Cell junction. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > tight junction. Cell junction > synapse > synaptosome. Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hLin 7 antibody
    • hLin7 antibody
    • LIN 7 antibody
    • Lin 7 homolog A antibody
    • LIN 7A antibody
    • LIN 7B antibody
    • LIN 7C antibody
    • Lin-7C antibody
    • Lin7 homolog A antibody
    • LIN7A antibody
    • LIN7C antibody
    • LIN7C_HUMAN antibody
    • MALS 1 antibody
    • MALS antibody
    • MALS-3 antibody
    • MALS1 antibody
    • Mammalian LIN 7 1 antibody
    • Mammalian lin seven protein 1 antibody
    • Mammalian lin-seven protein 3 antibody
    • Mammalian LIN7 1 antibody
    • MGC148143 antibody
    • Protein lin 7 homolog B antibody
    • Protein lin 7 homolog C antibody
    • Protein lin-7 homolog C antibody
    • protein lin7 homolog A antibody
    • Tax interaction protein 33 antibody
    • TIP 33 antibody
    • TIP33 antibody
    • VELI 1 antibody
    • Veli 1 protein antibody
    • Veli-3 antibody
    • VELI1 antibody
    • Velis antibody
    • Vertebrate LIN 7 homolog 1 antibody
    • Vertebrate lin-7 homolog 3 antibody
    • Vertebrate LIN7 homolog 1 antibody
    see all

Anti-LIN7 antibody (ab11472)参考文献

This product has been referenced in:
  • Humar B  et al. Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. Cancer Res 67:2480-9 (2007). Read more (PubMed: 17363565) »

See 1 Publication for this product

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