Anti-LIME抗体[LIME-06] (Phycoerythrin) (ab64678)

概述

  • 产品名称
    Anti-LIME抗体[LIME-06] (Phycoerythrin)
    参阅全部 LIME 一抗
  • 描述
    小鼠单克隆抗体[LIME-06] to LIME (Phycoerythrin)
  • 偶联物
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • 经测试应用
    适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment corresponding to aa 141-295 of human LIME.

  • 阳性对照
    • Peripheral blood T cells stimulated with anti-human CD4.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C.
  • 存储溶液
    Preservative: 15mM Sodium Azide
    Constituents: 0.2% BSA, PBS
  • Concentration information loading...
  • 纯度
    Size exclusion
  • 纯化说明
    Purified antibody (>95% by SDS-PAGE) was conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate was purified by size-exclusion chromatography.
  • 克隆
    单克隆
  • 克隆编号
    LIME-06
  • 同种型
    IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab64678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use a concentration of 5 µg/ml.

靶标

  • 相关性
    LIME (Lck-interacting molecule) is a new raft-associated adaptor protein involved in regulation of T cell activation by coreceptors. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation.
  • 细胞定位
    Cell membrane; Single-pass type III membrane protein. Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T cell with antigen presenting cell
  • 数据库链接
  • 别名
    • dJ583P15.4 antibody
    • FLJ20406 antibody
    • Lck interacting membrane protein antibody
    • Lck interacting molecule antibody
    • Lck interacting transmembrane adaptor 1 antibody
    • LIME 1 antibody
    • LIME1 antibody
    • LP8067 antibody
    • RP4 583P15.5 antibody
    see all

文献

ab64678 has not yet been referenced specifically in any publications.

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