概述

  • 产品名称
  • 描述
    兔多克隆抗体to LILRB1
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 600 to the C-terminus of Human LILRB1.

  • 阳性对照
    • Bone Marrow (Human) Tissue Lysate - adult normal tissue; Spleen (Human) Tissue Lysate - adult normal tissue; Thymus (Human) Tissue Lysate - adult normal tissue

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab77291 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 71 kDa (predicted molecular weight: 71 kDa).

靶标

  • 功能
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • 组织特异性
    Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells.
  • 序列相似性
    Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • 结构域
    Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 翻译后修饰
    Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD85 antibody
    • CD85 antigen antibody
    • CD85 antigen like family member J antibody
    • CD85 antigen-like family member J antibody
    • CD85j antibody
    • CD85j antigen antibody
    • Ig like transcript 2 antibody
    • ILT 2 antibody
    • ILT-2 antibody
    • ILT2 antibody
    • immunoglobulin like transcript 2 antibody
    • Immunoglobulin-like transcript 2 antibody
    • leukocyte Ig like receptor 1 antibody
    • Leukocyte immunoglobulin like receptor 1 antibody
    • leukocyte immunoglobulin like receptor subfamily B member 1 antibody
    • Leukocyte immunoglobulin like receptor subfamily B member 1 precursor antibody
    • leukocyte immunoglobulin like receptor subfamily B member 1 soluble isoform antibody
    • leukocyte immunoglobulin like receptor, subfamily B, member 1 antibody
    • Leukocyte immunoglobulin-like receptor 1 antibody
    • Leukocyte immunoglobulin-like receptor subfamily B member 1 antibody
    • leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform antibody
    • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 antibody
    • LILRB1 antibody
    • LIR 1 antibody
    • LIR-1 antibody
    • LIR1 antibody
    • LIRB1_HUMAN antibody
    • MIR 7 antibody
    • MIR-7 antibody
    • MIR7 antibody
    • Monocyte/macrophage immunoglobulin like receptor 7 antibody
    • Monocyte/macrophage immunoglobulin-like receptor 7 antibody
    • PIR B antibody
    • PIRB antibody
    see all

图片

  • All lanes : Anti-LILRB1 antibody (ab77291) at 1 µg/ml

    Lane 1 : Bone Marrow (Human) Tissue Lysate - adult normal tissue
    Lane 2 : Human spleen tissue lysate - total protein (ab29699)
    Lane 3 : Human thymus tissue lysate - total protein (ab30146)

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 71 kDa
    Observed band size : 71 kDa
    Additional bands at : 24 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 5 minutes

实验方案

文献

ab77291 has not yet been referenced specifically in any publications.

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