概述

  • 产品名称Anti-LILRB1抗体
    参阅全部 LILRB1 一抗
  • 描述
    小鼠多克隆抗体to LILRB1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-650 of Human LILRB1

性能

应用

Our Abpromise guarantee covers the use of ab67532 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: 1/500 - 1/1000. Predicted molecular weight: 71 kDa.
    Detection Pair

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
    • 组织特异性Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells.
    • 序列相似性Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
    • 结构域Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    • 翻译后修饰Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD85 antibody
      • CD85 antigen antibody
      • CD85 antigen like family member J antibody
      • CD85 antigen-like family member J antibody
      • CD85j antibody
      • CD85j antigen antibody
      • Ig like transcript 2 antibody
      • ILT 2 antibody
      • ILT-2 antibody
      • ILT2 antibody
      • immunoglobulin like transcript 2 antibody
      • Immunoglobulin-like transcript 2 antibody
      • leukocyte Ig like receptor 1 antibody
      • Leukocyte immunoglobulin like receptor 1 antibody
      • leukocyte immunoglobulin like receptor subfamily B member 1 antibody
      • Leukocyte immunoglobulin like receptor subfamily B member 1 precursor antibody
      • leukocyte immunoglobulin like receptor subfamily B member 1 soluble isoform antibody
      • leukocyte immunoglobulin like receptor, subfamily B, member 1 antibody
      • Leukocyte immunoglobulin-like receptor 1 antibody
      • Leukocyte immunoglobulin-like receptor subfamily B member 1 antibody
      • leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform antibody
      • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 antibody
      • LILRB1 antibody
      • LIR 1 antibody
      • LIR-1 antibody
      • LIR1 antibody
      • LIRB1_HUMAN antibody
      • MIR 7 antibody
      • MIR-7 antibody
      • MIR7 antibody
      • Monocyte/macrophage immunoglobulin like receptor 7 antibody
      • Monocyte/macrophage immunoglobulin-like receptor 7 antibody
      • PIR B antibody
      • PIRB antibody
      see all

    Anti-LILRB1 antibody 图像

    • All lanes : Anti-LILRB1 antibody (ab67532) at 1/500 dilution

      Lane 1 : LILRB1 transfected cell lysate
      Lane 2 : Non-transfected cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

      Predicted band size : 71 kDa

    Anti-LILRB1 antibody (ab67532)参考文献

    ab67532 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab67532.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"