Anti-LIFR抗体[MM0455-9B23] (ab89792)

概述

  • 产品名称Anti-LIFR抗体[MM0455-9B23]
    参阅全部 LIFR 一抗
  • 描述
    小鼠单克隆抗体[MM0455-9B23] to LIFR
  • 经测试应用适用于: WB, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Extracellular domain of Human recombinant LIFR protein

性能

应用

Our Abpromise guarantee covers the use of ab89792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/2000. Predicted molecular weight: 124 kDa.
Flow Cyt 1/50 - 1/200.

靶标

  • 功能Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
  • 疾病相关Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also knowns as Schwartz-Jampel syndrome type 2 (SJS2). SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue.
    Note=A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 6 fibronectin type-III domains.
  • 结构域The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD118 antibody
    • CD118 antigen antibody
    • FLJ98106 antibody
    • FLJ99923 antibody
    • Leukemia inhibitory factor receptor alpha antibody
    • Leukemia inhibitory factor receptor antibody
    • LIF R antibody
    • LIF receptor antibody
    • LIF-R antibody
    • Lifr antibody
    • LIFR_HUMAN antibody
    • SJS2 antibody
    • STWS antibody
    • SWS antibody
    see all

Anti-LIFR antibody [MM0455-9B23] (ab89792)参考文献

ab89792 has not yet been referenced specifically in any publications.

Product Wall


Hela cells were used to test this antibody in flow cytometry. As the immunogen of the antibody is extracellular domain, a regular flow cytometry protocol (without membrane permeabilization is needed) was applied.

Our recommended protocol ...

Read More

Ich verstehe Ihre Bedenken.

Es tut mir leid, dass ich Ihnen in diesem Fall nicht mehr helfen konnte.

Ich wünsche Ihnen alles Gute bei der Suche und viel Erfolg mit Ihrem Experiment.

Sorry for the delay in getting back to you.

I now have some further information to share with you in regards to the antibody ab89792. This antibody is a mouse monoclonal which has been raised against a recombinant fragment of the human LIFR p...

Read More

Thank you for contacting us and sorry for the delay in getting back to you.

I am going to have a look into the antibody ab89792 for you to see what I can suggest. I am not sure I will be able to provide the blocking peptide to this antibody b...

Read More

Thank you for confirming those details.

As requested, I have generated the testing discount code for you as below:

Discount code: xxxxxxx


Expiration date: 5th November 2012

Please orderab89792 as normalandqu...

Read More

Thank you for contacting us.

Unfortunately, due to the size of our catalogue and the logistics it would involve, we are unable to offer samples sizes of any of out products. However, if you would like to participate in the testing discount sc...

Read More

Es freut mich zu hören, dass Sie unser Angebot unseren Antikörper ab89792 Anti-LIFR antibody [MM0455-9B23] in IHC zu testen, annehmen möchten. Wie am Telefon besprochen, können Sie den Gutscheincode zum Kauf eines weiteren Antikörpers einsetzen, sobald...

Read More

Vielen Dank für Ihren Anruf und für Ihr Interesse an unseren Produkten.

Unseres Wissens nach wurde der ab89792 Anti-LIFR antibody [MM0455-9B23] bisher noch nicht in IHC getestet. Falls Sie dies selbst testen möchten, kann ich Ihnen zur Zeit ...

Read More

Thank you for contacting us and your interest in our products.


I have looked into whether the Anti-LIFR antibody (ab89792) could be successfully used with mouse samples. The antibody is raised against the extracellular domain of human L...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"