概述

  • 产品名称
  • 描述
    兔多克隆抗体to LDHA
  • 经测试应用
    适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Rabbit, Goat, Horse, Guinea pig, Cow, Cat, Dog, Chimpanzee, Spider monkey
  • 免疫原

    Synthetic peptide designed within residues: ATLKDQLIYN LLKEEQTPQN KITVVGVGAV GMACAISILM KDLADELALV, corresponding to N terminal amino acids 2-51 of Human LDHA (NP_005557)

  • 阳性对照
    • Human placenta lysate

性能

应用

Our Abpromise guarantee covers the use of ab84716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 通路
    Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
  • 疾病相关
    Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.
  • 序列相似性
    Belongs to the LDH/MDH superfamily. LDH family.
  • 翻译后修饰
    ISGylated.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cell proliferation-inducing gene 19 protein antibody
    • GSD11 antibody
    • L lactate dehydrogenase A chain antibody
    • L-lactate dehydrogenase A chain antibody
    • l7R2 antibody
    • Lactate dehydrogenase 1, A chain antibody
    • Lactate dehydrogenase A antibody
    • Lactate dehydrogenase A4 antibody
    • Lactate dehydrogenase M antibody
    • LDH A antibody
    • LDH M antibody
    • LDH muscle subunit antibody
    • LDH muscle subunit; M LDH antibody
    • LDH-A antibody
    • LDH-M antibody
    • LDH1 antibody
    • ldha antibody
    • LDHA_HUMAN antibody
    • LDHM antibody
    • OTTMUSP00000017774 antibody
    • PIG19 antibody
    • Proliferation-inducing gene 19 antibody
    • Renal carcinoma antigen NY-REN-59 antibody
    see all

Anti-LDHA antibody 图像

  • Immunohistochemistry (Formlin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue sections labeling LDHA with ab84716.

  • Anti-LDHA antibody (ab84716) at 1 µg/ml + Human placenta lysate at 10 µg

    Secondary
    anti-Rabbit IgG HRP at 1/50000 dilution

    Predicted band size : 37 kDa
    Observed band size : 37 kDa

Anti-LDHA antibody (ab84716)参考文献

This product has been referenced in:
  • Cui XG  et al. HIF1/2a mediates hypoxia-induced LDHA expression in human pancreatic cancer cells. Oncotarget 8:24840-24852 (2017). WB ; Human . Read more (PubMed: 28193910) »

See 1 Publication for this product

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