概述

  • 产品名称Anti-LDB3抗体
    参阅全部 LDB3 一抗
  • 描述
    山羊多克隆抗体to LDB3
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Dog, Pig
  • 免疫原

    Synthetic peptide:

    KSQNKPEDEADE

    , corresponding to Internal sequence amino acids 251-262 of Human LDB3

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab40840 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3 - 6 µg/ml.
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 77 kDa.

靶标

  • 功能May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
  • 组织特异性Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.
  • 疾病相关Defects in LDB3 are the cause of cardiomyopathy dilated type 1C (CMD1C) [MIM:601493]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in LDB3 are the cause of left ventricular non-compaction type 3 (LVNC3) [MIM:601493]. Left ventricular non-compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle.
    Defects in LDB3 are the cause of myopathy myofibrillar ZASP-related (MFM-ZASP) [MIM:609452]. A neuromuscular disorder characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy.
  • 序列相似性Contains 3 LIM zinc-binding domains.
    Contains 1 PDZ (DHR) domain.
  • 细胞定位Cytoplasm > perinuclear region. Cell projection > pseudopodium. Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CMD1C antibody
    • CYPHER antibody
    • HGNC:15710 antibody
    • KIAA01613 antibody
    • KIAA0613 antibody
    • Ldb3 antibody
    • LDB3_HUMAN antibody
    • LDB3Z1 antibody
    • LDB3Z4 antibody
    • LIM domain binding 3 antibody
    • LIM domain binding protein 3 antibody
    • LIM domain-binding protein 3 antibody
    • LVNC3 antibody
    • ORACLE antibody
    • PDLIM6 antibody
    • PDZ and LIM domain 6 antibody
    • Protein cypher antibody
    • Z band alternatively spliced PDZ motif antibody
    • Z band alternatively spliced PDZ motif protein antibody
    • Z-band alternatively spliced PDZ-motif protein antibody
    • ZASP antibody
    see all

Anti-LDB3 antibody 图像

  • Anti-LDB3 antibody (ab40840) at 0.01 µg/ml + Human Muscle lysate (35µg protein in RIPA buffer).

    Predicted band size : 77 kDa
  • ab40840 at 3.8 µg/ml staining LBD3 in Human Skeletal muscle by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with citrate pH 6, AP-staining.

Anti-LDB3 antibody (ab40840)参考文献

This product has been referenced in:

See 1 Publication for this product

Product Wall

Thank you again for your call yesterday and for letting us know about the trouble with the new lot of this antibody.
I've heard back from the lab, and the new batch of ab40840 passed QC testing, however it did need to be used at a much higher conc...

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Thank you for your call today and for letting us know about the trouble with this antibody.
As we discussed, I'm sending a free of charge replacement vial on the order ***, which should arrive tomorrow. I've also asked the lab if they are producin...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"