概述

  • 产品名称
    Anti-LCT抗体
  • 描述
    兔多克隆抗体to LCT
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence corresponding to amino acids 180-328 of Human LCT.

  • 阳性对照
    • Human stomach tissue
  • 常规说明
    Store product undiluted. The antibody solution should be gently mixed before use.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab121260 was affinity purified using the PrEST antigen as affinity ligand and is mono-specific.
  • 克隆
    多克隆
  • 同种型
    IgG

应用

Our Abpromise guarantee covers the use of ab121260 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/200. Perform Heat Induced Epitope Retrieval (HIER) at pH 6.

靶标

  • 功能
    LPH splits lactose in the small intestine.
  • 组织特异性
    Intestine.
  • 疾病相关
    Defects in LCT are the cause of congenital lactase deficiency (COLACD) [MIM:223000]; also known as hereditary alactasia or disaccharide intolerance II. Congenital lactase deficiency is a an autosomal recessive, rare and severe gastrointestinal disorder. It is characterized by watery diarrhea in infants fed with breast milk or other lactose-containing formulas. An almost total lack of LCT activity is found in jejunal biopsy material of patients with congenital lactase deficiency. Opposite to congenital lactase deficiency, adult-type hypolactasia, also known as lactose intolerance, is the most common enzyme deficiency worldwide. It is caused by developmental down-regulation of lactase activity during childhood or early adulthood. The decline of lactase activity is a normal physiological phenomenon; however, the majority of Northern Europeans have the ability to maintain lactase activity and digest lactose throughout life (lactase persistence). The down-regulation of lactase activity operates at the transcriptional level and it is associated with a noncoding variation in the MCM6 gene, located in the upstream vicinity of LCT.
  • 序列相似性
    Belongs to the glycosyl hydrolase 1 family.
  • 结构域
    The sequence exhibits 4 regions (I-IV) of internal homology; therefore LPH might have evolved by two cycles of partial gene duplication.
  • 细胞定位
    Apical cell membrane. Brush border.
  • Information by UniProt
  • 数据库链接
  • 别名
    • LAC antibody
    • Lactase antibody
    • Lactase phlorizin hydrolase 1 antibody
    • Lactase phlorizin hydrolase antibody
    • Lactase-glycosylceramidase antibody
    • Lct antibody
    • LPH antibody
    • LPH_HUMAN antibody
    • LPH1 antibody
    • Phlorizin hydrolase antibody
    see all

Anti-LCT antibody 图像

  • ab121260, at 1/300 dilution, staining LCT in paraffin-embedded Human stomach tissue by Immunohistochemistry, showing strong cytoplasmic positivity in glandular cells.

Anti-LCT antibody (ab121260)参考文献

ab121260 has not yet been referenced specifically in any publications.

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