Anti-LATS1 +LATS2 (phospho T1079 + T1041)抗体(ab111344)

概述

  • 产品名称Anti-LATS1 +LATS2 (phospho T1079 + T1041)抗体
    参阅全部 LATS1 +LATS2 一抗
  • 描述
    兔多克隆抗体to LATS1 +LATS2 (phospho T1079 + T1041)
  • 特异性ab111344 detects endogenous levels of LATS1 +LATS2 only when phosphorylated at threonine 1079/1041.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from C-terminal region of Human LATS1 +LATS2 around the phosphorylation site of threonine 1079/1041 (E-F-TP-F-R).

  • 阳性对照
    • Human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab111344 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 相关性Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.
  • 细胞定位Cytoplasm; cytoskeleton; centrosome.
  • 数据库链接
  • 别名
    • 4932411G09Rik antibody
    • AV277261 antibody
    • AW208599 antibody
    • AW228608 antibody
    • FLJ13161 antibody
    • KPM antibody
    • Large tumor supressor, homolog 1 antibody
    • LATS, large tumor suppressor, homolog 1 (Drosophila) antibody
    • LATS, large tumor suppressor, homolog 2 (Drosophila) antibody
    • RGD1564085 antibody
    • Serine/threonine protein kinase LATS1 antibody
    • Serine/threonine protein kinase LATS2 antibody
    • WARTS antibody
    • WARTS protein kinase antibody
    • wts antibody
    see all

Anti-LATS1 +LATS2 (phospho T1079 + T1041) antibody 图像

  • ab111344 at 1/50 dilution staining LATS1 +LATS2 in paraffin-embedded Human Brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-LATS1 +LATS2 (phospho T1079 + T1041) antibody (ab111344)参考文献

ab111344 has not yet been referenced specifically in any publications.

Product Wall

Application Immunocytochemistry
Sample Human Cultured Cells (immortalised glioma cell lines U343 and U87)
Permeabilization Yes - 0.1% Triton-X-100
Specification immortalised glioma cell lines U343 and U87
Fixative Paraformaldehyde
Username

Ms. Katherine Eales

Verified customer

提交于 Nov 29 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"