Anti-LATS1抗体(ab70562)

概述

• 产品名称Anti-LATS1抗体
  参阅全部 LATS1 一抗
• 描述
  兔多克隆抗体to LATS1
• 经测试应用适用于: WB, IPmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
• 免疫原

  Synthetic peptide corresponding to a region between residue 1075 and the C terminus (residue 1130) of human LATS1 (SwissProt: O95835)

• 阳性对照
  • HeLa whole cell lysate

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液Preservative: 0.09% Sodium Azide
  Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
• Concentration information loading...
• 纯度Immunogen affinity purified
• 纯化说明ab70562 was affinity purified using an epitope specific to LATS1 (WARTS) immobilized on solid support.
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Cell Biology
  • Cell Cycle
  • Kinases/Phosphatases
  • Cdk Regulators

  • Cell Biology
  • Cell Cycle
  • Cell Division
  • Cytokinesis

  • Cell Biology
  • Apoptosis
  • Intracellular
  • Kinases

  • Cancer
  • Oncoproteins/suppressors
  • Tumor suppressors
  • Other

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HeLa whole cell lysate (ab29545)

应用

靶标

• 功能Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
• 组织特异性Expressed in all adult tissues examined except for lung and kidney.
• 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  Contains 1 AGC-kinase C-terminal domain.
  Contains 1 protein kinase domain.
  Contains 1 UBA domain.
• 翻译后修饰Autophosphorylated and phosphorylated during M-phase of the cell cycle. Phosphorylated by STK3/MST2 at Ser-909 and Thr-1079, which results in its activation. Phosphorylation at Ser-464 by NUAK1 and NUAK2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy.
• 细胞定位Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.

• Target information above from: UniProt accession O95835 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 9113 Human
  • Entrez Gene: 16798 Mouse
  • Entrez Gene: 308265 Rat
  • Omim: 603473 Human
  • SwissProt: O95835 Human
  • SwissProt: Q8BYR2 Mouse
  • Unigene: 549084 Human
  • Unigene: 34083 Mouse

  • Unigene: 29152 Rat

  see all
• 别名
  • h-warts antibody
  • Large tumor suppressor homolog 1 antibody
  • LATS large tumor suppressor homolog 1 antibody

  • LATS1 antibody
  • LATS1_HUMAN antibody
  • Serine threonine protein kinase LATS1 antibody
  • Serine/threonine-protein kinase LATS1 antibody
  • WARTS antibody
  • WARTS protein kinase antibody
  • wts antibody

  see all