Anti-LAT2抗体[8B12] (ab123896)


  • 产品名称Anti-LAT2抗体[8B12]
    参阅全部 LAT2 一抗
  • 描述
    小鼠单克隆抗体[8B12] to LAT2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Human LAT2 protein expressed in 293T cells.

  • 阳性对照
    • HEK293T cells transfected with the pCMV6-ENTRY LAT2; Human kidney carcinoma tissue.
  • 常规说明Dilute in PBS (pH7.3) before use.



Our Abpromise guarantee covers the use of ab123896 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 58 kDa.
IHC-P 1/50.


  • 功能Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
  • 组织特异性Strongest expression is observed in kidney and moderate expression in placenta and brain, followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2.
  • 序列相似性Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
  • 细胞定位Cytoplasm. Basolateral cell membrane. Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hLAT2 antibody
    • integral membrane protein E16H antibody
    • L type amino acid transporter 2 antibody
    • L-type amino acid transporter 2 antibody
    • Large neutral amino acids transporter small subunit 2 antibody
    • LAT2_HUMAN antibody
    • LPI PC1 antibody
    • SLC7A8 antibody
    • solute carrier family 7 (amino acid transporter light chain, L system), member 8 antibody
    • solute carrier family 7 (amino acid transporter, L type), member 8 antibody
    • solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 antibody
    • Solute carrier family 7 member 8 antibody
    see all

Anti-LAT2 antibody [8B12] 图像

  • All lanes : Anti-LAT2 antibody [8B12] (ab123896) at 1/500 dilution

    Lane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNA
    Lane 2 : HEK293T cells transfected with pCMV6-ENTRY LAT2 cDNA

    Lysates/proteins at 5 µg per lane.

    Predicted band size : 58 kDa
    HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC204737)
  • ab123896, at 1/50, staining LAT2 in paraffin-embedded Human kidney carcinoma tissue by immunohistochemistry.

Anti-LAT2 antibody [8B12] (ab123896)参考文献

ab123896 has not yet been referenced specifically in any publications.

Product Wall

Vielen Dank fürIhre Email.

Es tut mir sehr leid zu hören, dass das Sie nicht die volle Menge an Produkt erhalten haben. Ich habe eine kostenlose Ersatzlieferung mit der Bestellnummer xxx in Auftrag gegeben. Sie werden in Kürze...

Read More

Vielen Dank für Ihre Anfrage.

Gerne bin ich Ihnen bei der Wahl eines passenden Antikörpers behilflich. Für welche Spezies suchen Sie den den Antikörper?

Ich freue mich auf Ihre Antwort.