Anti-LAT抗体[Y109] (ab32070)

概述

• 产品名称
  Anti-LAT抗体[Y109]
  参阅全部 LAT 一抗
• 描述
  兔单克隆抗体[Y109] to LAT
• 特异性
  This antibody is specific for LAT. It detects the long and short forms of LAT.
• 经测试应用
  适用于: WB, IHC-P, Flow Cyt, IPmore details
  不适用于: ICC
• 种属反应性
  与反应: Human
  
• 免疫原

  Synthetic peptide corresponding to residues surrounding the GRB2 binding motif 2 of Human LAT.

• 阳性对照
  • WB: Jurkat cell lysate. IHC-P: Human lymph node.
• 常规说明

  This product is a recombinant rabbit monoclonal antibody.

   

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

  Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab^® patents

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Concentration information loading...
• 克隆
  单克隆
• 克隆编号
  Y109
• 同种型
  IgG
• 研究领域
  • Immunology
  • Adaptive Immunity
  • T Cells
  • Non-CD

  • Signal Transduction
  • Adapters
  • Transmembrane

  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Ras Family

相关产品

• Immunohistochemistry kits
  • EXPOSE Rabbit specific HRP/DAB detection IHC kit (ab80437)
• Positive Controls
  • Jurkat whole cell lysate (ab7899)

应用

靶标

• 功能
  Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
• 组织特异性
  Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
• 翻译后修饰
  Phosphorylated on tyrosines by ZAP-70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ.
  Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.
• 细胞定位
  Cell membrane. Present in lipid rafts.

• Target information above from: UniProt accession O43561 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 27040 Human
  • Omim: 602354 Human
  • SwissProt: O43561 Human
  • Unigene: 632179 Human
• 别名
  • 36 kDa phospho tyrosine adapter protein antibody
  • 36 kDa phospho-tyrosine adapter protein antibody
  • 36 kDa phospho-tyrosine adaptor protein antibody

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