概述

  • 产品名称Anti-Langerin抗体
    参阅全部 Langerin 一抗
  • 描述
    兔多克隆抗体to Langerin
  • 经测试应用适用于: WB, IHC-FoFrmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    SPVLRKPLC

    , corresponding to N terminal amino acids 36-44 of Mouse Langerin (Genbank Accession No. CAC82936).

  • 阳性对照
    • Mouse lung tissue lysate

性能

应用

Our Abpromise guarantee covers the use of ab22111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-FoFr
  • 应用说明IHC-FoFr: 1/5000 - 1/10000 (PMID 19712927).
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 36 kDa (predicted molecular weight: 37 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
    • 组织特异性Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
    • 疾病相关Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
    • 序列相似性Contains 1 C-type lectin domain.
    • 结构域The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.
    • 细胞定位Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C type lectin domain family 4 member K antibody
      • C-type lectin domain family 4 member K antibody
      • CD 207 antibody
      • CD207 antibody
      • CD207 antigen antibody
      • CD207 antigen, langerin antibody
      • CD207 molecule antibody
      • CLC4K_HUMAN antibody
      • CLEC 4K antibody
      • CLEC4K antibody
      • Langerhans cell specific c type lectin antibody
      • Langerin antibody
      • RGD1565913 antibody
      see all

    Anti-Langerin antibody 图像

    • All lanes : Anti-Langerin antibody (ab22111) at 2 µg/ml

      Lane 1 : Mouse lung tissue lysate
      Lane 2 : Mouse lung tissue lysate with Preincubation with immunizing peptide


      Predicted band size : 37 kDa
      Observed band size : 36 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 30 kDa,70 kDa. We are unsure as to the identity of these extra bands.

    Anti-Langerin antibody (ab22111)参考文献

    This product has been referenced in:
    • Hara Y  et al. Up-regulation of vascular endothelial growth factor expression by adenosine through adenosine A2 receptors in the rat tongue treated with endotoxin. Arch Oral Biol 54:932-42 (2009). IHC-FoFr ; Rat . Read more (PubMed: 19712927) »
    • Yu X  et al. Engagement of CD47 inhibits the contact hypersensitivity response via the suppression of motility and B7 expression by Langerhans cells. J Invest Dermatol 126:797-807 (2006). Read more (PubMed: 16456531) »

    See all 2 Publications for this product

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    I am very pleased to hear you would like to accept our offer and test ab22111 inIHC-P. This code will give you: 1 free primary antibody before the expiration date. To redeem this offer, please submit an Abreview forIHC-P and include this code in t...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"