Anti-Langerin抗体(ab125476)

概述

  • 产品名称Anti-Langerin抗体
    参阅全部 Langerin 一抗
  • 描述
    兔多克隆抗体to Langerin
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow, Cat, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 262-311: GDWSWVDDTP FNKVQSARFW IPGEPNNAGN NEHCGNIKAP SLQAWNDAPC, of Human Langerin. (NP_056532).

性能

应用

Our Abpromise guarantee covers the use of ab125476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
  • 组织特异性Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
  • 疾病相关Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
  • 序列相似性Contains 1 C-type lectin domain.
  • 结构域The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.
  • 细胞定位Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C type lectin domain family 4 member K antibody
    • C-type lectin domain family 4 member K antibody
    • CD 207 antibody
    • CD207 antibody
    • CD207 antigen antibody
    • CD207 antigen, langerin antibody
    • CD207 molecule antibody
    • CLC4K_HUMAN antibody
    • CLEC 4K antibody
    • CLEC4K antibody
    • Langerhans cell specific c type lectin antibody
    • Langerin antibody
    • RGD1565913 antibody
    see all

Anti-Langerin antibody 图像

  • Anti-Langerin antibody (ab125476) at 1 µg + Fetal kidney

    Predicted band size : 37 kDa

Anti-Langerin antibody (ab125476)参考文献

ab125476 has not yet been referenced specifically in any publications.

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Vielen Dank für Ihre Anrufe.

Wie versprochen habe ich alle unsere Langerin- bzw. TACD2-Antikörper danach geprüft, ob sie schon einmal mit Schwein getestet wurden - was leider bei keinem der Fall ist.

Daher habe ich di...

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