概述

  • 产品名称Anti-LAMTOR1抗体
    参阅全部 LAMTOR1 一抗
  • 描述
    兔多克隆抗体to LAMTOR1
  • 经测试应用适用于: ICC/IF, IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 9-156 of Human LAMTOR1.

  • 阳性对照
    • Human rectum tissue; RT4, U251 MG and Human liver lysates; A431 cells.

应用

Our Abpromise guarantee covers the use of ab121157 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 1 - 4 µg/ml. Using PFA/Triton X-100 fixation.
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

靶标

  • 功能Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
  • 序列相似性Belongs to the LAMTOR1 family.
  • 细胞定位Late endosome membrane. Lysosome membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C11orf59 antibody
    • LAMTOR1 antibody
    • Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 antibody
    • Lipid raft adaptor protein p18 antibody
    • LTOR1_HUMAN antibody
    • p18 antibody
    • p27Kip1-releasing factor from RhoA antibody
    • p27RF-Rho antibody
    • PDRO antibody
    • PP7157 antibody
    • Protein associated with DRMs and endosomes antibody
    • Ragulator complex protein LAMTOR1 antibody
    • ragulator complex protein PDRO antibody
    • Ragulator1 antibody
    • RhoA activator C11orf59 antibody
    see all

Anti-LAMTOR1 antibody 图像

  • ab121157 at 1/350 dilution staining LAMTOR1 in Paraffin-emebedded Human Rectum tissue by Immunohistochemistry.

    Note:strong cytoplasmic positivity, with a granular pattern, in glandular cells.
  • ab121157 at 4 µg/ml staining LAMTOR1 (green staining) in A431 cells, using PFA/Triton X-100 fixation by Immunofluorescence.

    Note: positivity in plasma membrane & golgi apparatus.
  • All lanes : Anti-LAMTOR1 antibody (ab121157) at 1/250 dilution

    Lane 1 : RT4 lysate
    Lane 2 : U251 MG lysate
    Lane 3 : Human plamsa
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

Anti-LAMTOR1 antibody (ab121157)参考文献

ab121157 has not yet been referenced specifically in any publications.

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