概述

  • 产品名称Anti-LAMP2抗体[M3/84]
    参阅全部 LAMP2 一抗
  • 描述
    大鼠单克隆抗体[M3/84] to LAMP2
  • 经测试应用适用于: IP, Flow Cyt, IHC-Frmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Glycoproteins purified from mouse peritoneal macrophage membranes.

性能

应用

Our Abpromise guarantee covers the use of ab23822 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent concentration.
Flow Cyt 1/50 - 1/100. Use 10µl of this concentration to label 106 cells in 100µl. As the expression of LAMP2 is predominantly cytoplasmic results are imprved by the use of a membrane permeabilisation procedure prior to staining.



ab18407-Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IHC-Fr Use at an assay dependent concentration.

靶标

  • 功能Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
  • 组织特异性Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
  • 疾病相关Defects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
  • 序列相似性Belongs to the LAMP family.
  • 翻译后修饰O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
  • 细胞定位Cell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane.
  • Information by UniProt
  • 数据库链接
  • 形式Alternative splicing produces 3 isoforms.
  • 别名
    • CD107 antigen-like family member B antibody
    • CD107b antibody
    • LAMP 2 antibody
    • LAMP 2C antibody
    • LAMP-2 antibody
    • LAMP2 antibody
    • LAMP2_HUMAN antibody
    • LAMPB antibody
    • LGP110 antibody
    • Lysosomal associated membrane protein 2 antibody
    • Lysosome associated membrane protein 2 antibody
    • Lysosome-associated membrane glycoprotein 2 antibody
    • Lysosome-associated membrane protein 2 antibody
    • MAC3 antibody
    see all

Anti-LAMP2 antibody [M3/84] (ab23822)参考文献

This product has been referenced in:
  • Flotte TJ  et al. Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets. Am J Pathol 111:112-24 (1983). Read more (PubMed: 6340516) »
  • Springer TA Monoclonal antibody analysis of complex biological systems. Combination of cell hybridization and immunoadsorbents in a novel cascade procedure and its application to the macrophage cell surface. J Biol Chem 256:3833-9 (1981). Read more (PubMed: 7217058) »

See all 2 Publications for this product

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