Anti-LAMP2抗体[H4B4] (Phycoerythrin) (ab25368)

概述

  • 产品名称
    Anti-LAMP2抗体[H4B4] (Phycoerythrin)
    参阅全部 LAMP2 一抗
  • 描述
    小鼠单克隆抗体[H4B4] to LAMP2 (Phycoerythrin)
  • 偶联物
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特异性
    Human CD107b/LAMP-2
  • 经测试应用
    适用于: Flow Cyt, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    The details of the immunogen for this antibody are not available.

应用

Our Abpromise guarantee covers the use of ab25368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 10µl for 106 cells. ab91357-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IHC-Fr Use at an assay dependent concentration.

靶标

  • 功能
    Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
  • 组织特异性
    Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
  • 疾病相关
    Defects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
  • 序列相似性
    Belongs to the LAMP family.
  • 翻译后修饰
    O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
  • 细胞定位
    Cell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane.
  • Information by UniProt
  • 数据库链接
  • 形式
    Alternative splicing produces 3 isoforms.
  • 别名
    • CD107 antigen like family member B antibody
    • CD107 antigen-like family member B antibody
    • CD107b antibody
    • LAMP 2 antibody
    • LAMP 2C antibody
    • LAMP-2 antibody
    • LAMP2 antibody
    • LAMP2_HUMAN antibody
    • LAMPB antibody
    • LGP 96 antibody
    • LGP110 antibody
    • LGP96 antibody
    • Lysosomal associated membrane protein 2 antibody
    • Lysosome associated membrane glycoprotein 2 antibody
    • Lysosome associated membrane protein 2 antibody
    • Lysosome-associated membrane glycoprotein 2 antibody
    • Lysosome-associated membrane protein 2 antibody
    • MAC3 antibody
    see all

Anti-LAMP2 antibody [H4B4] (Phycoerythrin) 图像

  • Flow cytometry analysis staining LAMP2 in cells using ab25368 at a dilution of 10 μg/10⁶ cells.

Anti-LAMP2 antibody [H4B4] (Phycoerythrin) (ab25368)参考文献

This product has been referenced in:
  • Wang AL  et al. Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS One 4:e4160 (2009). Flow Cyt ; Human . Read more (PubMed: 19129916) »

See 1 Publication for this product

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