Anti-LAMP2抗体[H4B4] (Biotin) (ab25447)

概述

  • 产品名称Anti-LAMP2抗体[H4B4] (Biotin)
    参阅全部 LAMP2 一抗
  • 描述
    小鼠单克隆抗体[H4B4] to LAMP2 (Biotin)
  • 偶联物Biotin
  • 特异性Human CD107b/LAMP-2
  • 经测试应用适用于: Flow Cyt, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    The details of the immunogen for this antibody are not available.

应用

Our Abpromise guarantee covers the use of ab25447 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
IHC-Fr
  • 应用说明Flow Cyt: Use 10µl for 106 cells.
    IHC-Acetone fixed Frozen sections: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
    • 组织特异性Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
    • 疾病相关Defects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
    • 序列相似性Belongs to the LAMP family.
    • 翻译后修饰O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
    • 细胞定位Cell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane.
    • Information by UniProt
    • 数据库链接
    • 形式Alternative splicing produces 3 isoforms.
    • 别名
      • CD107 antigen-like family member B antibody
      • CD107b antibody
      • LAMP 2 antibody
      • LAMP 2C antibody
      • LAMP-2 antibody
      • LAMP2 antibody
      • LAMP2_HUMAN antibody
      • LAMPB antibody
      • LGP110 antibody
      • Lysosomal associated membrane protein 2 antibody
      • Lysosome associated membrane protein 2 antibody
      • Lysosome-associated membrane glycoprotein 2 antibody
      • Lysosome-associated membrane protein 2 antibody
      • MAC3 antibody
      see all

    Anti-LAMP2 antibody [H4B4] (Biotin) (ab25447)参考文献

    ab25447 has not yet been referenced specifically in any publications.

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