Anti-Laminin 2 alpha抗体[2D4] (ab117608)

概述

  • 产品名称Anti-Laminin 2 alpha抗体[2D4]
    参阅全部 Laminin 2 alpha 一抗
  • 描述
    小鼠单克隆抗体[2D4] to Laminin 2 alpha
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Human Laminin Alpha 2 (NP_000417.2).

  • 阳性对照
    • Human Placenta (Trophoblast) tissue.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab117608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 344 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 组织特异性Placenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung, spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, and some other regions of the brain; not in liver, thymus and bone.
  • 疾病相关Defects in LAMA2 are the cause of merosin-deficient congenital muscular dystrophy type 1A (MDC1A) [MIM:607855]. MDC1A is characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI.
  • 序列相似性Contains 17 laminin EGF-like domains.
    Contains 5 laminin G-like domains.
    Contains 2 laminin IV type A domains.
    Contains 1 laminin N-terminal domain.
  • 结构域The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    Domains VI, IV and G are globular.
  • 细胞定位Secreted > extracellular space > extracellular matrix > basement membrane. Major component.
  • Information by UniProt
  • 数据库链接
  • 别名
    • LAMA 2 antibody
    • LAMA2 antibody
    • LAMA2_HUMAN antibody
    • Laminin alpha 2 (merosin congenital muscular dystrophy) antibody
    • Laminin alpha 2 antibody
    • Laminin alpha 2 chain antibody
    • Laminin alpha 2 subunit antibody
    • Laminin M antibody
    • Laminin M chain antibody
    • Laminin subunit alpha-2 antibody
    • Laminin-12 subunit alpha antibody
    • Laminin-2 subunit alpha antibody
    • Laminin-4 subunit alpha antibody
    • LAMM antibody
    • Merosin heavy chain antibody
    see all

Anti-Laminin 2 alpha antibody [2D4] 图像

  • ab117608, at 5 µg/ml, staining Laminin 2 alpha in Formalin-fixed, Paraffin-embedded Human Placenta (Trophoblast) tissue by Immunohistochemistry.

Anti-Laminin 2 alpha antibody [2D4] (ab117608)参考文献

ab117608 has not yet been referenced specifically in any publications.

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