概述

  • 产品名称Anti-LAMC2抗体
    参阅全部 LAMC2 一抗
  • 描述
    兔多克隆抗体to LAMC2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Dog
  • 免疫原

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 445 and 627 of Human LAMC2

  • 阳性对照
    • Raji whole cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab96327 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 131 kDa.

靶标

  • 功能Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
  • 组织特异性The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli.
  • 疾病相关Defects in LAMC2 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB) [MIM:226700]; also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic.
  • 序列相似性Contains 8 laminin EGF-like domains.
    Contains 1 laminin IV type A domain.
  • 结构域The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    Domain IV is globular.
  • 细胞定位Secreted > extracellular space > extracellular matrix > basement membrane. Major component.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3918 antibody
    • B2T antibody
    • BM600 antibody
    • Cell-scattering factor 140 kDa subunit antibody
    • CSF 140 kDa subunit antibody
    • CSF antibody
    • EBR2 antibody
    • EBR2A antibody
    • Epiligrin subunit gamma antibody
    • Kalinin subunit gamma antibody
    • Kalinin/nicein/epiligrin 100 kDa subunit antibody
    • Ladsin 140 kDa subunit antibody
    • LAMB2T antibody
    • LAMC2 antibody
    • LAMC2_HUMAN antibody
    • Laminin 5 gamma 2 subunit antibody
    • Laminin B2t chain antibody
    • Laminin gamma 2 antibody
    • laminin gamma 2 chain antibody
    • Laminin subunit gamma-2 antibody
    • Laminin-5 subunit gamma antibody
    • LAMNB2 antibody
    • Large adhesive scatter factor 140 kDa subunit antibody
    • MGC138491 antibody
    • MGC141938 antibody
    • Nicein subunit gamma antibody
    • NICEIN-100KDA antibody
    see all

Anti-LAMC2 antibody 图像

  • Anti-LAMC2 antibody (ab96327) at 1/1000 dilution + Raji cell lysate at 30 µg

    Predicted band size : 131 kDa

Anti-LAMC2 antibody (ab96327)参考文献

ab96327 has not yet been referenced specifically in any publications.

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