Lactacystin,proteasome抑制剂(ab141411)
Key features and details
- Cell-permeable, potent and selective proteasome inhibitor
- CAS Number: 133343-34-7
- Purity: > 95%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
Lactacystin,proteasome抑制剂 -
描述
Cell-permeable,potent and selective proteasome抑制剂 -
生物学描述
Potent, irreversible, cell-permeable, selective 20S proteasome inhibitor (IC50 = 70 nM). Inhibits cell-cycle progression and induces neurite outgrowth in vitro. Anti-bacterial and antitumor agent. Active in vivo and in vitro. -
纯度
> 95% -
常规说明
This product is manufactured by BioVision, an Abcam company and was previously called 1709 Lactacystin (Synthetic). 1709-200 is the same size as the 200 µg size of ab141411.
-
CAS编号
133343-34-7 -
化学结构
性能
-
化学名称
2-Acetamido-3-[3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid -
分子量
376.42 -
分子式
C15H24N2O7S -
PubChem识别号
3870 -
存放说明
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC1C(C(NC1=O)(C(C(C)C)O)C(=O)SCC(C(=O)O)NC(=O)C)O -
来源
Synthetic
-
研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
-
SDS download
-
Datasheet download
文献 (4)
ab141411 被引用在 4 文献中.
- Cursano S et al. A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome. Mol Psychiatry N/A:N/A (2020). PubMed: 32051550
- Song L et al. KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a. Nat Commun 10:1639 (2019). PubMed: 30967557
- Park H et al. Tumor Inhibitory Effect of IRCR201, a Novel Cross-Reactive c-Met Antibody Targeting the PSI Domain. Int J Mol Sci 18:N/A (2017). PubMed: 28902178
- Zhang K et al. Berberine induces hERG channel deficiency through trafficking inhibition. Cell Physiol Biochem 34:691-702 (2014). PubMed: 25171176