概述

  • 产品名称Anti-L2HGDH抗体
  • 描述
    兔多克隆抗体to L2HGDH
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 139-167 of Human L2HGDH (NP_079160.1).

  • 阳性对照
    • MDA-MB435 cell line and Mouse kidney tissue lysates

性能

应用

Our Abpromise guarantee covers the use of ab108012 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

靶标

  • 组织特异性Widely expressed. Highly expressed in brain, testis and muscle. Expressed to a lower extent in lymphocytes, fibroblasts, keratinocytes, placenta, bladder, small intestine, liver and bone marrow.
  • 疾病相关Defects in L2HGDH are the cause of L-2-hydroxyglutaric aciduria (L2HGA) [MIM:236792]. L2HGA is a rare autosomal recessive disorder clinically characterized by mild psychomotor delay in the first years of life, followed by progressive cerebellar ataxia, dysarthria and moderate to severe mental retardation. Diagnosis is based on the presence of an excess of L-2-hydroxyglutaric acid in urine, blood and cerebrospinal fluid.
  • 序列相似性Belongs to the L2HGDH family.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2 hydroxyglutarate dehydrogenase antibody
    • Alpha hydroxyglutarate oxidoreductase antibody
    • Alpha ketoglutarate reductase antibody
    • C14orf160 antibody
    • Duranin antibody
    • FLJ12618 antibody
    • L alpha hydroxyglutarate dehydrogenase antibody
    • L-2-hydroxyglutarate dehydrogenase antibody
    • L-2-hydroxyglutarate dehydrogenase, mitochondrial antibody
    • L2HDH_HUMAN antibody
    • l2hgdh antibody
    • mitochondrial antibody
    see all

Anti-L2HGDH antibody 图像

  • Anti-L2HGDH antibody (ab108012) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg/ml

    Predicted band size : 50 kDa
  • Anti-L2HGDH antibody (ab108012) at 1/100 dilution + Mouse kidney tissue lysates at 35 µg

    Predicted band size : 50 kDa

Anti-L2HGDH antibody (ab108012)参考文献

ab108012 has not yet been referenced specifically in any publications.

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