Anti-L-Kynurenine Hydrolase抗体(ab96365)

概述

  • 产品名称Anti-L-Kynurenine Hydrolase抗体
    参阅全部 L-Kynurenine Hydrolase 一抗
  • 描述
    兔多克隆抗体to L-Kynurenine Hydrolase
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 114 and 299 of Human L-Kynurenine Hydrolase (AAH00879).

  • 阳性对照
    • A549 cell lysate

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab96365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.

靶标

  • 功能Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
  • 组织特异性Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
  • 通路Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
    Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
  • 疾病相关Note=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively.
  • 序列相似性Belongs to the kynureninase family.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • kynU antibody
    • KYNU_HUMAN antibody
    • kynureninase (L-kynurenine hydrolase) antibody
    • Kynureninase antibody
    • L-kynurenine hydrolase antibody
    see all

Anti-L-Kynurenine Hydrolase antibody 图像

  • Anti-L-Kynurenine Hydrolase antibody (ab96365) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 35 kDa

Anti-L-Kynurenine Hydrolase antibody (ab96365)参考文献

ab96365 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab96365.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"