概述

  • 产品名称Anti-L-Kynurenine Hydrolase抗体
    参阅全部 L-Kynurenine Hydrolase 一抗
  • 描述
    小鼠单克隆抗体to L-Kynurenine Hydrolase
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 2-109 of Human L-Kynurenine Hydrolase

性能

应用

Our Abpromise guarantee covers the use of ab56450 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ICC/IF
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
    • 组织特异性Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
    • 通路Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
      Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
    • 疾病相关Note=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively.
    • 序列相似性Belongs to the kynureninase family.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • kynU antibody
      • KYNU_HUMAN antibody
      • kynureninase (L-kynurenine hydrolase) antibody
      • Kynureninase antibody
      • L-kynurenine hydrolase antibody
      see all

    Anti-L-Kynurenine Hydrolase antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56450 L-Kynurenine Hydrolase antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-L-Kynurenine Hydrolase antibody (ab56450)参考文献

    This product has been referenced in:
    • Yang G  et al. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. J Exp Med 210:241-56 (2013). ICC/IF . Read more (PubMed: 23359068) »

    See 1 Publication for this product

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