概述

  • 产品名称
    L-655,240
  • 描述
    Potent thromboxane A2 receptor antagonist
  • 生物学描述
    Potent thromboxane A2 receptor antagonist (IC50 = 7 nM). Blocks TP-mediated bronchoconstriction in vivo and platelet aggregation ex vivo. Orally active in vivo.
  • 纯度
    > 98%

性能

  • 化学名称
    1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid
  • 分子量
    373.85
  • 化学结构
    Chemical Structure
  • 分子式
    C21H21ClFNO2
  • CAS编号
    103253-15-2
  • 存放说明
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in ethanol to 50 mM and in DMSO to 50 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    ClC1=CC=C(CN2C(CC(C)(C)C(O)=O)=C(C)C3=CC(F)=CC=C32)C=C1
  • 来源

    Synthetic

  • 研究领域

    L-655,240 (ab120946)参考文献

    This product has been referenced in:
    • Ogletree ML & Allen GT Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J Pharmacol Exp Ther 260:789-94 (1992). Read more (PubMed: 1531361) »
    • Wainwright CL & Parratt JR The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J Cardiovasc Pharmacol 12:264-71 (1988). Read more (PubMed: 2464097) »
    • Hall RA  et al. Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpro pan oic acid); a potent, selective thromboxane/prostaglandin endoperoxide antagonist. Eur J Pharmacol 135:193-201 (1987). Read more (PubMed: 3582493) »

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