概述

  • 产品名称L-655,240
  • 描述
    Potent thromboxane A2 receptor antagonist
  • 生物学描述Potent thromboxane A2 receptor antagonist (IC50 = 7 nM). Blocks TP-mediated bronchoconstriction in vivo and platelet aggregation ex vivo. Orally active in vivo.
  • 纯度> 98%

性能

    L-655,240 (ab120946)参考文献

    This product has been referenced in:
    • Ogletree ML & Allen GT Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J Pharmacol Exp Ther 260:789-94 (1992). Read more (PubMed: 1531361) »
    • Wainwright CL & Parratt JR The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J Cardiovasc Pharmacol 12:264-71 (1988). Read more (PubMed: 2464097) »
    • Hall RA  et al. Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpro pan oic acid); a potent, selective thromboxane/prostaglandin endoperoxide antagonist. Eur J Pharmacol 135:193-201 (1987). Read more (PubMed: 3582493) »

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