功能Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
组织特异性Highly expressed throughout the brain. Expression is very low or absent in other tissues.
序列相似性Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
结构域The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
翻译后修饰Phosphorylated on serine and threonine residues.
细胞定位Cell membrane. Cell projection > dendrite. Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression.