Anti-Kv2.1 (phospho S567)抗体(ab61107)

概述

• 产品名称Anti-Kv2.1 (phospho S567)抗体
  参阅全部 Kv2.1 一抗
• 描述
  兔多克隆抗体to Kv2.1 (phospho S567)
• 特异性ab61107 detects endogenous levels of Kv2.1/KCNB1 only when phosphorylated at tyrosine 128.
• 经测试应用适用于: ELISA, IHC-Pmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat
• 免疫原

  Synthetic peptide corresponding to Human Kv2.1.

• 阳性对照
  • Human brain tissue.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• 存储溶液Preservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS (without Mg²⁺ and Ca²⁺), 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• 纯度Immunogen affinity purified
• 纯化说明The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Neuroscience
  • Neurotransmission
  • Receptors / Channels
  • Potassium Channels

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
• 序列相似性Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
• 结构域The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
• 翻译后修饰Highly phosphorylated on serine residues in the C-terminal. Differential phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are all regulated by calcineurin-mediated dephosphorylation. Particularly, Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/ dephosphorylation activities. Tyr-128 can be dephosphorylated by PTPalpha and cyt-PTPepsilon. Phosphorylation levels on Ser-607 are supersensitive to neuronal activity. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5. Levels then increase to reach adult levels by P14. Phosphorylation levels on Ser-564 and Ser-607 are greatly reduced during seizures, by 40% and 85% respectively.
• 细胞定位Membrane.

• Target information above from: UniProt accession Q14721 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 3745 Human
  • Entrez Gene: 16500 Mouse
  • Entrez Gene: 25736 Rat
  • Omim: 600397 Human
  • SwissProt: Q14721 Human
  • SwissProt: Q03717 Mouse
  • SwissProt: P15387 Rat
  • Unigene: 84244 Human

  • Unigene: 387390 Mouse
  • Unigene: 26724 Rat

  see all
• 别名
  • Delayed rectifier potassium channel 1 antibody
  • Delayed rectifier potassium channel Kv2.1 antibody
  • DRK 1 antibody

  • DRK1 antibody
  • h DRK1 K(+) channel antibody
  • h-DRK1 antibody
  • hDRK 1 antibody
  • hDRK1 antibody
  • KCB 1 antibody
  • KCB1 antibody
  • KCNB1 antibody
  • KCNB1_HUMAN antibody
  • KV2.1 antibody
  • Potassium channel protein DRK1 antibody
  • Potassium voltage gated channel shab related subfamily member 1 antibody
  • Potassium voltage-gated channel subfamily B member 1 antibody
  • Voltage-gated potassium channel subunit Kv2.1 antibody

  see all