概述

  • 产品名称Anti-Kv beta 1抗体[S40-17]
    参阅全部 Kv beta 1 一抗
  • 描述
    小鼠单克隆抗体[S40-17] to Kv beta 1
  • 经测试应用适用于: ICC/IF, IHC-P, IHC-Fr, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Full length protein, corresponding to amino acids 1 - 401 of Rat Kv beta 1 (P63144).

  • 阳性对照
    • Rat brain lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20ºC.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 50% Glycerol, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号S40-17
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab99012 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 0.1 - 1 µg/ml. (perox) or 1 - 10 µg/ml (IF).
IHC-P Use a concentration of 0.1 - 1 µg/ml. (perox) or 1 - 10 µg/ml (IF).
IHC-Fr Use a concentration of 0.1 - 1 µg/ml. (perox) or 1 - 10 µg/ml (IF).
WB Use a concentration of 1 µg/ml. Detects a band of approximately 30 - 45 kDa.

靶标

  • 功能Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.
  • 组织特异性In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.
  • 序列相似性Belongs to the shaker potassium channel beta subunit family.
  • 结构域Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hKvb3 antibody
    • hKvBeta3 antibody
    • K(+) channel subunit beta-1 antibody
    • KCAB1_HUMAN antibody
    • KCNA1B antibody
    • KCNAB1 antibody
    • Kv-beta-1 antibody
    • Kvb1.3 antibody
    • Voltage-gated potassium channel beta-1 subunit antibody
    • Voltage-gated potassium channel subunit beta-1 antibody
    see all

Anti-Kv beta 1 antibody [S40-17] 图像

  • Image from David M et al., J Biol Chem. 2012 Jun 15;287(25):21416-28. Epub 2012 Apr 30.Fig 10.; doi: 10.1074/jbc.M111.328278; June 15, 2012, The Journal of Biological Chemistry, 287, 21416-21428.

Anti-Kv beta 1 antibody [S40-17] (ab99012)参考文献

This product has been referenced in:
  • David M  et al. Protein Kinase C (PKC) Activity Regulates Functional Effects of Kvß1.3 Subunit on KV1.5 Channels: IDENTIFICATION OF A CARDIAC Kv1.5 CHANNELOSOME. J Biol Chem 287:21416-28 (2012). WB ; Human . Read more (PubMed: 22547057) »

See 1 Publication for this product

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