概述

  • 产品名称KT5823
  • 描述
    Potent, selective inhibitor of PKG
  • 生物学描述Potent, selective, reversible inhibitor of Protein Kinase G (PKG) (Ki = 234 nM). Derivative of K252, selective over PKA and PKC (Ki values are >10 and 4 μM, respectively). Prevents increased phosphorylation of regulators of G-protein-signalling in vivo.
  • 纯度> 95%

性能

  • 化学名称(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
  • 分子量495.53
  • 化学结构Chemical Structure
  • 分子式C29H25N3O5
  • CAS编号126643-37-6
  • PubChem识别号108152
  • 存放说明Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in DMSO to 50 mM and in ethanol to 2.5 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESO=C(OC)[C@]8(C[C@H]7O[C@]8(C)n4c3c1n7c6ccccc6c1c2c(CN(C)C2=O)c3c5ccccc45)OC
  • 来源

    Synthetic

  • 研究领域

    KT5823 (ab120423)参考文献

    This product has been referenced in:
    • Chan SL & Fiscus RR Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod 9:775-83 (2003). Read more (PubMed: 14614039) »
    • Burkhardt M  et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem 275:33536-41 (2000). Read more (PubMed: 10922374) »
    • Levander-Lindgren M ECG telemetry for pacemaker check-up. Acta Med Scand Suppl 596:72-6 (1976). Read more (PubMed: 1070230) »

    See 0 Publications for this product

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