概述

  • 产品名称Anti-KSR1抗体
    参阅全部 KSR1 一抗
  • 描述
    兔多克隆抗体to KSR1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Dog, Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 500 - 600 of Human KSR1.

  • 阳性对照
    • This antibody gave a positive signal in Mouse brain tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab98204 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 105 kDa (predicted molecular weight: 97 kDa).

靶标

  • 功能Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
  • 序列相似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 protein kinase domain.
  • 翻译后修饰Phosphorylated on Ser-309 and, to a higher extent, on Ser-404 by MARK3. Dephosphorylated on Ser-404 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated.
  • 细胞定位Cytoplasm. Membrane. In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BKSR 1 antibody
    • BKSR1 antibody
    • dKsr antibody
    • EK 31 antibody
    • EK31 antibody
    • hb antibody
    • Kinase suppressor of Ras 1 antibody
    • Kinase suppressor of ras antibody
    • KSR 1 antibody
    • KSR antibody
    • KSR1 antibody
    • KSR1_HUMAN antibody
    • Positive Ras signaling mediator family member (86.4 kD) antibody
    • Positive Ras signaling mediator family member antibody
    • RSU 2 antibody
    • RSU2 antibody
    • SR 31 antibody
    • SR31 antibody
    • Suppressor of activated let 60 Ras SUR3 antibody
    • Suppressor of Ras1 31 antibody
    see all

Anti-KSR1 antibody 图像

  • Anti-KSR1 antibody (ab98204) at 1 µg/ml + Brain (Mouse) Tissue Lysate at 10 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 97 kDa
    Observed band size : 105 kDa (why is the actual band size different from the predicted?)


    Exposure time : 8 minutes

Anti-KSR1 antibody (ab98204)参考文献

ab98204 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab98204.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"