概述

  • 产品名称
  • 描述
    山羊多克隆抗体to KPNA6
  • 经测试应用
    适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide:

    C-STTGESVITREMVE

    , corresponding to internal sequence amino acids 74-87 of Human KPNA6

  • 阳性对照
    • Human adrenal tissue, Human prostate tissue, Human muscle lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab110016 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 60 kDa.
IHC-P Use a concentration of 3.75 µg/ml.
ELISA 1/128000.

靶标

  • 功能
    Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
  • 组织特异性
    Widely expressed.
  • 序列相似性
    Belongs to the importin alpha family.
    Contains 10 ARM repeats.
    Contains 1 IBB domain.
  • Information by UniProt
  • 数据库链接
  • 形式
    Cellular location: cytoplasm; nucleus.
  • 别名
    • FLJ11249 antibody
    • IMA7_HUMAN antibody
    • Importin alpha 7 subunit antibody
    • Importin alpha S2 antibody
    • Importin subunit alpha 7 antibody
    • Importin subunit alpha-7 antibody
    • IPOA 7 antibody
    • IPOA7 antibody
    • Karyopherin alpha 6 antibody
    • Karyopherin alpha 6 (importin alpha 7) antibody
    • Karyopherin subunit alpha 6 antibody
    • Karyopherin subunit alpha-6 antibody
    • KPNA 6 antibody
    • KPNA 7 antibody
    • Kpna6 antibody
    • KPNA7 antibody
    • MGC17918 antibody
    • OTTHUMP00000004532 antibody
    see all

图片

  • ab110016, at 3.75 µg/ml, staining KPNA6 in Human adrenal tissue by immunohistochemistry.
  • ab110016, at 3.75 µg/ml, staining KPNA6 in Human prostate tissue by immunohistochemistry.
  • Anti-KPNA6 antibody (ab110016) at 0.1 µg/ml + Human muscle lysate (in RIPA buffer) at 35 µg

    Predicted band size : 60 kDa

文献

ab110016 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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