概述
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产品名称Anti-KPNA6抗体
参阅全部 KPNA6 一抗 -
描述兔多克隆抗体to KPNA6
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宿主Rabbit
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经测试应用适用于: WBmore details
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种属反应性与反应: Human
预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
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免疫原
Synthetic peptide corresponding to a region within N terminal amino acids 74-123 (STTGESVITR EMVEMLFSDD SDLQLATTQK FRKLLSKEPS PPIDEVINTP) of Human KPNA6 (NP_036448).
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阳性对照
- Human fetal brain lysate
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
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存储溶液Preservative: None
Constituents: 2% Sucrose, PBS -
Concentration information loading... -
纯度Immunogen affinity purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab104977 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T. |
靶标
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功能Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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组织特异性Widely expressed.
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序列相似性Belongs to the importin alpha family.
Contains 10 ARM repeats.
Contains 1 IBB domain. - Information by UniProt
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数据库链接
- Entrez Gene: 23633 Human
- Entrez Gene: 16650 Mouse
- Entrez Gene: 362607 Rat
- Omim: 610563 Human
- SwissProt: Q0V7M0 Cow
- SwissProt: O60684 Human
- SwissProt: O35345 Mouse
- Unigene: 470588 Human
see all -
形式Cellular location: cytoplasm; nucleus.
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别名
- FLJ11249 antibody
- IMA7_HUMAN antibody
- Importin alpha 7 subunit antibody
see all
图片
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Western blot - KPNA6 antibody (ab104977)Anti-KPNA6 antibody (ab104977) at 1 µg/ml + Human fetal brain lysate at 10 µg
Predicted band size: 60 kDa
Gel concentration: 12%
文献
ab104977 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"