概述

  • 产品名称Anti-KPNA6抗体
    参阅全部 KPNA6 一抗
  • 描述
    兔多克隆抗体to KPNA6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 74-123 (STTGESVITR EMVEMLFSDD SDLQLATTQK FRKLLSKEPS PPIDEVINTP) of Human KPNA6 (NP_036448).

  • 阳性对照
    • Human fetal brain lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab104977 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the importin alpha family.
    Contains 10 ARM repeats.
    Contains 1 IBB domain.
  • Information by UniProt
  • 数据库链接
  • 形式Cellular location: cytoplasm; nucleus.
  • 别名
    • FLJ11249 antibody
    • IMA7_HUMAN antibody
    • Importin alpha 7 subunit antibody
    • Importin alpha S2 antibody
    • Importin subunit alpha 7 antibody
    • Importin subunit alpha-7 antibody
    • IPOA 7 antibody
    • IPOA7 antibody
    • Karyopherin alpha 6 antibody
    • Karyopherin alpha 6 (importin alpha 7) antibody
    • Karyopherin subunit alpha 6 antibody
    • Karyopherin subunit alpha-6 antibody
    • KPNA 6 antibody
    • KPNA 7 antibody
    • Kpna6 antibody
    • KPNA7 antibody
    • MGC17918 antibody
    • OTTHUMP00000004532 antibody
    see all

Anti-KPNA6 antibody 图像

  • Anti-KPNA6 antibody (ab104977) at 1 µg/ml + Human fetal brain lysate at 10 µg

    Predicted band size : 60 kDa

Anti-KPNA6 antibody (ab104977)参考文献

ab104977 has not yet been referenced specifically in any publications.

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