Anti-KPNA6抗体(ab104977)

概述

• 产品名称Anti-KPNA6抗体
  参阅全部 KPNA6 一抗
• 描述
  兔多克隆抗体to KPNA6
• 经测试应用适用于: WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
• 免疫原

  Synthetic peptide corresponding to a region within N terminal amino acids 74-123 (STTGESVITR EMVEMLFSDD SDLQLATTQK FRKLLSKEPS PPIDEVINTP) of Human KPNA6 (NP_036448).

  Run BLAST with Run BLAST with
• 阳性对照
  • Human fetal brain lysate

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• 存储溶液Preservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• 纯度Immunogen affinity purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Signal Transduction
  • Protein Trafficking
  • Nuclear Import / Export

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
• 组织特异性Widely expressed.
• 序列相似性Belongs to the importin alpha family.
  Contains 10 ARM repeats.
  Contains 1 IBB domain.

• Target information above from: UniProt accession O60684 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 23633 Human
  • Entrez Gene: 16650 Mouse
  • Entrez Gene: 362607 Rat
  • Omim: 610563 Human
  • SwissProt: Q0V7M0 Cow
  • SwissProt: O60684 Human
  • SwissProt: O35345 Mouse
  • Unigene: 470588 Human

  • Unigene: 711019 Human
  • Unigene: 202358 Mouse
  • Unigene: 139167 Rat

  see all
• 形式Cellular location: cytoplasm; nucleus.
• 别名
  • FLJ11249 antibody
  • IMA7_HUMAN antibody
  • Importin alpha 7 subunit antibody

  • Importin alpha S2 antibody
  • Importin subunit alpha 7 antibody
  • Importin subunit alpha-7 antibody
  • IPOA 7 antibody
  • IPOA7 antibody
  • Karyopherin alpha 6 antibody
  • Karyopherin alpha 6 (importin alpha 7) antibody
  • Karyopherin subunit alpha 6 antibody
  • Karyopherin subunit alpha-6 antibody
  • KPNA 6 antibody
  • KPNA 7 antibody
  • Kpna6 antibody
  • KPNA7 antibody
  • MGC17918 antibody
  • OTTHUMP00000004532 antibody

  see all