Anti-KMT8/Riz1/Riz2抗体(ab3790)

Anti-KMT8/Riz1/Riz2抗体

兔多克隆抗体to KMT8/Riz1/Riz2

Rabbit

This antibody recognizes the beta isoform (Riz 2) of PRDM 2 (185 kDa) as well as RIZ 1. It will not detect isoform 4.

适用于: IP, WB, IHC-Pmore details

与反应: Mouse, Rat, Human

Fusion protein (GST-tag) corresponding to Rat KMT8/Riz1/Riz2 aa 245-573.

• IP: Rat B50 brain tumour cell lysate.

Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Preservative: 0.09% Sodium azide
Constituent: PBS

Protein A purified

This antibody is purified through a protein A column, followed by peptide affinity purification.

Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger gene RIZ 1 is a tumor suppressor gene and a founding member of the PR domain family. RIZ 1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ 1 is also a tumor susceptibility gene in mice. The loss of RIZ 1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ 1 promoter strongly correlated with lost or decreased RIZ 1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

多克隆

IgG

• Epigenetics and Nuclear Signaling
• Chromatin Modifying Enzymes
• Methylation

• Neuroscience
• Neurology process
• Neurogenesis

• Epigenetics and Nuclear Signaling
• Transcription
• Cancer susceptibility
• Tumor Suppressors

• Epigenetics and Nuclear Signaling
• Nuclear Signaling Pathways
• Nuclear Receptors
• Estrogen

• Epigenetics and Nuclear Signaling
• Transcription
• Co-factors

• Epigenetics and Nuclear Signaling
• Chromatin Modifying Enzymes
• Methylation
• Lysine methylation

• Cancer
• Oncoproteins/suppressors
• Tumor suppressors
• Rb family

• Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
• Goat Anti-Rabbit IgG H&L (HRP) (ab205718)