Anti-KMT3B / NSD1抗体(ab84137)


  • 产品名称Anti-KMT3B / NSD1抗体
    参阅全部 KMT3B / NSD1 一抗
  • 描述
    兔多克隆抗体to KMT3B / NSD1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to a region within residues 650 and 700 of human KMT3B/ NSD1 (SwissProt entry Q96L73).

  • 阳性对照
    • Human prostate adenocarcinoma.



Our Abpromise guarantee covers the use of ab84137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明IHC-P: 1/100 - 1/500.
    Epitope exposure is recommended.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.
    • 组织特异性Expressed in the fetal/adult brain, kidney, skeletal muscle, spleen, and the thymus, and faintly in the lung.
    • 疾病相关Defects in NSD1 are the cause of Sotos syndrome (SOTOSS) [MIM:117550]; also known as cerebral gigantism. It is a disorder characterized by excessively rapid growth, acromegalic features, and a nonprogressive cerebral disorder with mental retardation. High-arched palate and prominent jaw are noted in several patients. Most cases of Sotos syndrome are sporadic and may represent new dominant mutation.
      Defects in NSD1 are the cause of Weaver syndrome (WES) [MIM:277590]. WES is a syndrome of accelerated growth and osseous maturation, unusual craniofacial appearance, hoarse and low-pitched cry, and hypertonia with camptodactyly.
      Defects in NSD1 are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
      Note=A chromosomal aberration involving NSD1 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NUP98.
      Note=A chromosomal aberration involving NSD1 is found in an adult form of myelodysplastic syndrome (MDS). Insertion of NUP98 into NSD1 generates a NUP98-NSD1 fusion product.
    • 序列相似性Belongs to the histone-lysine methyltransferase family.
      Contains 1 AWS domain.
      Contains 4 PHD-type zinc fingers.
      Contains 1 post-SET domain.
      Contains 2 PWWP domains.
      Contains 1 SET domain.
    • 细胞定位Nucleus. Chromosome.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Androgen receptor coactivator 267 kDa protein antibody
      • Androgen receptor-associated protein of 267 kDa antibody
      • ARA267 antibody
      • H3 K36 HMTase antibody
      • H3-K36-HMTase antibody
      • H4 K20 HMTase antibody
      • H4-K20-HMTase antibody
      • Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific antibody
      • KMT3B antibody
      • Lysine N-methyltransferase 3B antibody
      • NR binding SET domain containing protein antibody
      • NR-binding SET domain-containing protein antibody
      • Nsd1 antibody
      • NSD1_HUMAN antibody
      • Nuclear receptor binding SET domain containing protein 1 antibody
      • Nuclear receptor-binding SET domain-containing protein 1 antibody
      see all

    Anti-KMT3B / NSD1 antibody 图像

    • ab84137, at a 1/250 dilution, staining KMT3B / NSD1 in formalin fixed, paraffin embedded human prostate adenocarcinoma by Immunohistochemistry.
      Detection: DAB

    Anti-KMT3B / NSD1 antibody (ab84137)参考文献

    ab84137 has not yet been referenced specifically in any publications.

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