概述

  • 产品名称Anti-KMT2H / ASH1抗体[ASH5H03]
    参阅全部 KMT2H / ASH1 一抗
  • 描述
    小鼠单克隆抗体[ASH5H03] to KMT2H / ASH1
  • 经测试应用适用于: Dot blot, WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment corresponding to Human KMT2H/ ASH1 aa 1611-1728.
    Sequence:

    IGSCRVSNPNSSGRKKLTDSPGLFSAQDTSLNRLHRKESLPSNERAVQTL AGSQPTSDKPSQRPSESTNCSPTRKRSSSESTSSTVNGVPSRSPRLVASG DDSVDSLLQRMVQNEDQE

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, 8mM Sodium phosphate, 3mM Potassium chloride, 140mM Sodium chloride, 1.5mM Potassium phosphate, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明ab50981 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum
  • 克隆单克隆
  • 克隆编号ASH5H03
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab50981 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Dot blot
WB
  • 应用说明Dot: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 330 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Histone methyltransferase. Probably methylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation.
    • 组织特异性Widely expressed, with highest level in brain, heart and kidney.
    • 序列相似性Belongs to the histone-lysine methyltransferase family. SET2 subfamily.
      Contains 3 A.T hook DNA-binding domains.
      Contains 1 AWS domain.
      Contains 1 BAH domain.
      Contains 1 bromo domain.
      Contains 1 PHD-type zinc finger.
      Contains 1 post-SET domain.
      Contains 1 SET domain.
    • 细胞定位Nucleus. Cell junction > tight junction. Chromosome. The relevance of tight junction localization is however unclear.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Absent small and homeotic disks protein 1 homolog antibody
      • Absent Small or Homeotic Like antibody
      • Absent Small or Homeotic Like antibody
      • ASH 1 antibody
      • ASH 1L antibody
      • ash1 (absent small or homeotic 1) antibody
      • Ash1 (absent small or homeotic) like antibody
      • ASH1-like protein antibody
      • ASH1L antibody
      • ASH1L_HUMAN antibody
      • ASH1L1 antibody
      • FLJ10504 antibody
      • huASH1 antibody
      • KIAA1420 antibody
      • Lysine N-methyltransferase 2H antibody
      • Probable histone-lysine N-methyltransferase ASH1L antibody
      see all

    Anti-KMT2H / ASH1 antibody [ASH5H03] 图像

    Anti-KMT2H / ASH1 antibody [ASH5H03] (ab50981)参考文献

    This product has been referenced in:
    • Atta H  et al. Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role of ASH1 and EZH2 methyltransferases repression. PLoS One 9:e112384 (2014). Dot blot . Read more (PubMed: 25380300) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"