Anti-KMT2G / hSET1B抗体(ab112049)

概述

  • 产品名称Anti-KMT2G / hSET1B抗体
    参阅全部 KMT2G / hSET1B 一抗
  • 描述
    兔多克隆抗体to KMT2G / hSET1B
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rabbit, Cow, Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region between amino acids 350-400 of KMT2G/ hSET1B (NP_055863.1).

  • 阳性对照
    • Human Breast Carcinoma, Human Ovarian Carcinoma, and Human Testicular Seminoma tissues

性能

应用

Our Abpromise guarantee covers the use of ab112049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

靶标

  • 功能Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
  • 序列相似性Contains 1 post-SET domain.
    Contains 1 RRM (RNA recognition motif) domain.
    Contains 1 SET domain.
  • 细胞定位Nucleus speckle. Chromosome. Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ20803 antibody
    • Histone-lysine N-methyltransferase SETD1B antibody
    • hSET1B antibody
    • KIAA1076 antibody
    • KMT2G antibody
    • Lysine N-methyltransferase 2G antibody
    • SET domain containing 1B antibody
    • SET domain-containing protein 1B antibody
    • SET1B antibody
    • SET1B_HUMAN antibody
    • SETD1B antibody
    see all

Anti-KMT2G / hSET1B antibody 图像

  • Staining of Human KMT2G / hSET1B in a Formalin/PFA-fixed paraffin-embedded section of Human Breast Carcinoma using ab112049 at a dilution of 1/250.
  • Staining of Human KMT2G / hSET1B in a Formalin/PFA-fixed paraffin-embedded section of Human Ovarian Carcinoma using ab112049 at a dilution of 1/250.

Anti-KMT2G / hSET1B antibody (ab112049)参考文献

ab112049 has not yet been referenced specifically in any publications.

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (HeLa)
Permeabilization Yes - 0.5% TritonX100 in PBS
Specification HeLa
Fixative Paraformaldehyde
Username

Dr. Kirk McManus

Verified customer

提交于 Aug 07 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"