概述

  • 产品名称Anti-KLRG1抗体[2F1] (FITC)
    参阅全部 KLRG1 一抗
  • 描述
    叙利亚仓鼠单克隆抗体[2F1] to KLRG1 (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 特异性This antibody is specific for KLRG1, MW 30-38kDa.
  • 经测试应用适用于: Flow Cyt, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Activated NK (A-LAK) cells from B6 (H-2b)mice.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度IgG fraction
  • 克隆单克隆
  • 克隆编号2F1
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab24867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 1µg for 106 cells. ab18420-Syrian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.

靶标

  • 功能Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
  • 组织特异性Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.
  • 序列相似性Contains 1 C-type lectin domain.
  • 结构域Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2F1 Ag antibody
    • 2F1 antibody
    • C type lectin domain family 15 member A antibody
    • C-type lectin domain family 15 member A antibody
    • CLEC15A antibody
    • ITIM containing receptor MAFA L antibody
    • ITIM-containing receptor MAFA-L antibody
    • Killer cell lectin like receptor G1 antibody
    • Killer cell lectin like receptor subfamily G member 1 antibody
    • Killer cell lectin-like receptor subfamily G member 1 antibody
    • KLRG 1 antibody
    • KLRG1 antibody
    • KLRG1 protein antibody
    • KLRG1_HUMAN antibody
    • MAFA 2F1 antibody
    • MAFA antibody
    • MAFA L antibody
    • MAFA like antibody
    • MAFA like receptor antibody
    • MAFA-like receptor antibody
    • MAFAL antibody
    • Mast cell function associated antigen (ITIM containing) antibody
    • Mast cell function associated antigen antibody
    • Mast cell function-associated antigen 2F1 antibody
    • Mast cell function-associated antigen antibody
    • Mast cell function-associated antigen, rat, homolog of antibody
    • MGC13600 antibody
    see all

Anti-KLRG1 antibody [2F1] (FITC) 图像

  • Flow cytometry analysis of splenocytes from mice, staining KLRG1 with ab24867.

Anti-KLRG1 antibody [2F1] (FITC) (ab24867)参考文献

This product has been referenced in:
  • Valkenburg SA  et al. Early priming minimizes the age-related immune compromise of CD8? T cell diversity and function. PLoS Pathog 8:e1002544 (2012). Flow Cyt ; Mouse . Read more (PubMed: 22383879) »
  • Durward M  et al. Active Evasion of CTL Mediated Killing and Low Quality Responding CD8+ T Cells Contribute to Persistence of Brucellosis. PLoS One 7:e34925 (2012). Flow Cyt ; Mouse . Read more (PubMed: 22558103) »

See all 4 Publications for this product

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