概述

  • 产品名称
    Anti-KLRG1抗体[2F1]
    参阅全部 KLRG1 一抗
  • 描述
    叙利亚仓鼠单克隆抗体[2F1] to KLRG1
  • 宿主
    Syrian hamster
  • 特异性
    ab25054 recognises KLRG1.
  • 经测试应用
    适用于: Flow Cyt, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Activated NK (A-LAK) cells from B6 (H-2b) mice

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C. Do Not Freeze.
  • 存储溶液
    pH: 7.2
    Preservative: 0.09% Sodium azide
    Constituents: 0.88% Sodium chloride, 0.12% Monobasic dihydrogen sodium phosphate
  • Concentration information loading...
  • 纯度
    Affinity purified
  • 纯化说明
    Purified from TCS
  • 克隆
    单克隆
  • 克隆编号
    2F1
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab25054 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration.

ab18474 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.

IP Use at an assay dependent concentration.

靶标

  • 功能
    Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
  • 组织特异性
    Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.
  • 序列相似性
    Contains 1 C-type lectin domain.
  • 结构域
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2F1 Ag antibody
    • 2F1 antibody
    • C type lectin domain family 15 member A antibody
    • C-type lectin domain family 15 member A antibody
    • CLEC15A antibody
    • ITIM containing receptor MAFA L antibody
    • ITIM-containing receptor MAFA-L antibody
    • Killer cell lectin like receptor G1 antibody
    • Killer cell lectin like receptor subfamily G member 1 antibody
    • Killer cell lectin-like receptor subfamily G member 1 antibody
    • KLRG 1 antibody
    • KLRG1 antibody
    • KLRG1 protein antibody
    • KLRG1_HUMAN antibody
    • MAFA 2F1 antibody
    • MAFA antibody
    • MAFA L antibody
    • MAFA like antibody
    • MAFA like receptor antibody
    • MAFA-like receptor antibody
    • MAFAL antibody
    • Mast cell function associated antigen (ITIM containing) antibody
    • Mast cell function associated antigen antibody
    • Mast cell function-associated antigen 2F1 antibody
    • Mast cell function-associated antigen antibody
    • Mast cell function-associated antigen, rat, homolog of antibody
    • MGC13600 antibody
    see all

文献

This product has been referenced in:
  • Corral L  et al. NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules. Eur J Immunol 30:920-30 (2000). Read more (PubMed: 10741410) »
  • Hanke T  et al. 2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells. Eur J Immunol 28:4409-17 (1998). Read more (PubMed: 9862378) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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