概述

  • 产品名称Anti-KLHL21抗体
  • 描述
    兔多克隆抗体to KLHL21
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment corresponding to a region within amino acids 345-520 of Human KLHL21

  • 阳性对照
    • WB: A549, HeLa, Jurkat and Raji whole cell lysates IHC-P: Hepatoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab111604 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 67 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with 10mM citrate buffer pH 6.0 or Tris-EDTA buffer pH 8.0 before commening with IHC staining protocol.

靶标

  • 功能Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 BACK (BTB/Kelch associated) domain.
    Contains 1 BTB (POZ) domain.
    Contains 6 Kelch repeats.
  • 细胞定位Cytoplasm > cytoskeleton > spindle. Localizes to the spindle midzone and targets CUL3 to this region.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Kelch-like protein 21 antibody
    • KIAA0469 antibody
    • KLH21_HUMAN antibody
    • KLHL21 antibody
    • MGC99635 antibody
    see all

Anti-KLHL21 antibody 图像

  • Anti-KLHL21 antibody (ab111604) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 67 kDa
  • ab111604, at a 1/500, staining KLHL21 in paraffin-embedded Hepatoma tissue.

Anti-KLHL21 antibody (ab111604)参考文献

ab111604 has not yet been referenced specifically in any publications.

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