概述

  • 产品名称Anti-KLHDC8B抗体
    参阅全部 KLHDC8B 一抗
  • 描述
    兔多克隆抗体to KLHDC8B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide within residues: SAGGGRAFAW QVFPPMPTCR VYGTVAHQDG HLLVLGGCGR AGLPLDTAET , corresponding to N terminal amino acids 2-51 of Human KLHDC8B (NP_775817)

  • 阳性对照
    • Human fetal stomach lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab89953 is purified by a peptide affinity chromatography method.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab89953 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 疾病相关Defects in KLHDC8B are a cause of Hodgkin lymphoma (HL) [MIM:236000]. A malignant disease characterized by progressive enlargement of the lymph nodes, spleen and general lymphoid tissue, and the presence of large, usually multinucleate, cells (Reed-Sternberg cells). Reed-Sternberg cells compose only 1-2% of the total tumor cell mass. The remainder is composed of a variety of reactive, mixed inflammatory cells consisting of lymphocytes, plasma cells, neutrophils, eosinophils and histiocytes. Note=A chromosomal aberration disrupting KLHDC8B has been found in a family with the nodular sclerosis type of classic Hodgkin lymphoma. Translocation t(2,3)(q11.2;p21.31).
  • 序列相似性Contains 8 Kelch repeats.
  • 发展阶段Transcribed predominantly during S phase, translated exclusively during mitosis and cytokinesis and rapidly degraded after cell division.
  • 细胞定位Cytoplasm. In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ11302 antibody
    • FP17659 antibody
    • Kelch domain containing 8B antibody
    • Kelch domain containing protein 8B antibody
    • Kelch domain-containing protein 8B antibody
    • KLD8B_HUMAN antibody
    • Klhdc8b antibody
    • MGC35097 antibody
    • MGC94736 antibody
    see all

Anti-KLHDC8B antibody 图像

  • Anti-KLHDC8B antibody (ab89953) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal stomach lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa

Anti-KLHDC8B antibody (ab89953)参考文献

ab89953 has not yet been referenced specifically in any publications.

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