概述

  • 产品名称Anti-KLF6抗体
    参阅全部 KLF6 一抗
  • 描述
    小鼠单克隆抗体to KLF6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-261 of Human KLF6

性能

应用

Our Abpromise guarantee covers the use of ab54568 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
    • 组织特异性Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.
    • 疾病相关Defects in KLF6 are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
      Defects in KLF6 are a cause of prostate cancer (PC) [MIM:176807]. Prostate cancer is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
    • 序列相似性Belongs to the krueppel C2H2-type zinc-finger protein family.
      Contains 3 C2H2-type zinc fingers.
    • 结构域The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • B cell derived protein 1 antibody
      • B cell-derived 1 antibody
      • B-cell-derived protein 1 antibody
      • BCD1 antibody
      • CBA1 antibody
      • COPEB antibody
      • Core promoter element-binding protein antibody
      • CPBP antibody
      • GBF antibody
      • GC rich binding factor antibody
      • GC rich sites binding factor GBF antibody
      • GC-rich sites-binding factor GBF antibody
      • Klf6 antibody
      • KLF6_HUMAN antibody
      • Krueppel-like factor 6 antibody
      • Krueppel-like factor 6 isoform C antibody
      • Kruppel like zinc finger protein Zf9 antibody
      • PAC1 antibody
      • Proto-oncogene BCD1 antibody
      • Protooncogene B cell derived 1 antibody
      • ST12 antibody
      • Suppression of tumorigenicity 12 (prostate) antibody
      • Suppressor of tumorigenicity 12 protein antibody
      • Transcription factor Zf9 antibody
      • Zf9 antibody
      see all

    Anti-KLF6 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab54568 KLF6 antibody at 1ug/ml. Predicted band size of immunogen is 55 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Anti-KLF6 antibody (ab54568)参考文献

    ab54568 has not yet been referenced specifically in any publications.

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