概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab37702 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    Blocking - Blocking peptide for Anti-Kisspeptin antibody (ab19028)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • KISS 1
    • KiSS 1 metastasis suppressor
    • Kiss1
    • KISS1_HUMAN
    • Kisspeptin
    • Kisspeptin 1
    • Kisspeptin 10
    • Kisspeptin 13
    • Kisspeptin 14
    • Kisspeptin-1
    • Kisspeptin-10
    • Kisspeptin-54
    • Kisspeptin1
    • Malignant melanoma metastasis suppressor
    • Metastasis suppressor KiSS 1
    • Metastasis suppressor KiSS1
    • Metastin
    • MGC39258
    see all
  • 功能Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
  • 组织特异性Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.
  • 序列相似性Belongs to the KISS1 family.
  • 翻译后修饰Processed by MMP2 and MMP9.
  • 细胞定位Secreted.
  • Information by UniProt

Kisspeptin peptide (ab37702)参考文献

ab37702 has not yet been referenced specifically in any publications.

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