概述

  • 产品名称Anti-Kir6.2抗体
    参阅全部 Kir6.2 一抗
  • 描述
    山羊多克隆抗体to Kir6.2
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Guinea pig
  • 免疫原

    Synthetic peptide:

    ERRARFVSKKGNC

    , corresponding to internal sequence amino acids 35-42 of Human Kir6.2 (NP_000516.3).

  • 阳性对照
    • Human Muscle lysate and Human Pancreas tissue

相关产品

应用

Our Abpromise guarantee covers the use of ab117079 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/64000.
WB Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 44 kDa.
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 相关性ATP-sensitive potassium (K(ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K(ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.
  • 细胞定位Cell Membrane; Multi-pass membrane protein
  • 数据库链接
  • 别名
    • ATP sensitive inward rectifier potassium channel 11 antibody
    • Beta cell inward rectifier subunit antibody
    • BIR antibody
    • HHF 2 antibody
    • HHF2 antibody
    • IKATP antibody
    • Inward rectifier K(+) channel Kir6.2 antibody
    • Inwardly rectifying potassium channel KIR6.2 antibody
    • IRK 11 antibody
    • IRK11 antibody
    • KCNJ11 antibody
    • Kir 6.2 antibody
    • Kir6.2 antibody
    • MGC133230 antibody
    • PHHI antibody
    • Potassium channel inwardly rectifing subfamily J member 11 antibody
    • Potassium channel, inwardly rectifying subfamily J member 11 antibody
    • Potassium inwardly rectifying channel J11 antibody
    • TNDM 3 antibody
    • TNDM3 antibody
    see all

Anti-Kir6.2 antibody 图像

  • Anti-Kir6.2 antibody (ab117079) at 0.01 µg/ml + Human Muscle lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 44 kDa
  • Human Pancreas (formalin-fixed, paraffin-embedded) stained with ab117079 at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Kir6.2 antibody (ab117079)参考文献

ab117079 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"