概述

  • 产品名称Anti-Kir4.1抗体
    参阅全部 Kir4.1 一抗
  • 描述
    兔多克隆抗体to Kir4.1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Horse, Cow, Human, Macaque Monkey, Gorilla, Chinese Hamster
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 300 to the C-terminus of Human Kir4.1.

  • 阳性对照
    • This antibody gave a positive signal in Mouse Spinal cord tissue lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituent: PBS
    Note: Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab101064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).

靶标

  • 功能May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
  • 组织特异性Expressed in kidney (at protein level).
  • 疾病相关Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance
  • 序列相似性Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
  • 细胞定位Membrane. Basolateral cell membrane. In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.
  • Information by UniProt
  • 数据库链接
  • 别名
    • inwardly rectifying subfamily J member 10 antibody
    • ATP dependent inwardly rectifying potassium channel Kir4.1 antibody
    • ATP sensitive inward rectifier potassium channel 10 antibody
    • ATP-dependent inwardly rectifying potassium channel Kir4.1 antibody
    • ATP-sensitive inward rectifier potassium channel 10 antibody
    • BIRK10 antibody
    • Glial ATP dependent inwardly rectifying potassium channel KIR4.1 antibody
    • Inward rectifier K(+) channel Kir1.2 antibody
    • Inward rectifier K+ channel KIR1.2 antibody
    • Inwardly rectifying potassium channel Kir1.2 antibody
    • KCJ10_HUMAN antibody
    • KCNJ 10 antibody
    • Kcnj10 antibody
    • KCNJ13 PEN antibody
    • KIR1.2 antibody
    • KIR4.1 antibody
    • Potassium channel antibody
    • Potassium channel inwardly rectifying subfamily J member 10 antibody
    • Potassium inwardly rectifying channel subfamily J member 10 antibody
    • SESAME antibody
    see all

Anti-Kir4.1 antibody 图像

  • Anti-Kir4.1 antibody (ab101064) at 1 µg/ml + Spinal Cord (Mouse) Tissue Lysate at 10 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 42 kDa


    Exposure time : 8 minutes

Anti-Kir4.1 antibody (ab101064)参考文献

ab101064 has not yet been referenced specifically in any publications.

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